 Defective RNA Editing Seen in Neurons of ALS Patients Findings from a new study show that mRNA for a subunit of glutamate receptors is not edited correctly in the spinal motor neurons of patients with amyotrophic lateral sclerosis (ALS). This could contribute to the neuronal death seen with ALS, according to the authors. Reuters Health Information 2004 Gene Targeting Disrupts Osteogenesis Imperfecta Mutation in Stem Cells Using viral vectors, US researchers have been able to target and eliminate the dominant gene mutations found in mesenchymal stem cells from patients with osteogenesis imperfecta. Reuters Health Information 2004 Adipocyte Hormone May Regulate Blood Glucose Levels, Linking Obesity to Diabetes Hepatic gluconeogenesis is reduced in mice lacking the adipocyte hormone resistin, Dr. Mitchell A. Lazar and colleagues report. In addition to at least partially explaining the role of obesity in the development of type 2 diabetes, targeting the resistin metabolic pathway may offer a new therapeutic strategy. Reuters Health Information 2004 One Vaccine Could Counter All HCV Strains Work in chimpanzees suggests that vaccination against one strain of hepatitis C virus (HCV) confers cross-genotype immunity. This study, lead investigator Dr. Robert E. Lanford told Reuters Health, "demonstrates for the first time that chimpanzees that develop immunity to one strain of HCV are immune to highly divergent strains -- genotypes." Reuters Health Information 2004 TNF Polymorphisms Tied to Hepatitis C Severity Tumor necrosis factor (TNF)-beta polymorphisms appear to be associated with greater disease severity in patients infected with hepatitis C virus (HCV), according to Indian researchers. Reuters Health Information 2004 Rhesus TRIM5-Alpha Blocks Uncoating of HIV-1 Capsid The non-human primate TRIM5-alpha protein, but not its human orthologue, impedes HIV-1 infection by targeting its capsid protein, Dr. Joseph Sodroski and fellow investigators at Harvard Medical School report. Reuters Health Information 2004 HIV Escape Mutations Do Not Always Survive Transmission HIV mutations that arise in order to escape cytotoxic T-lymphocyte (CTL) recognition do not necessarily lead to significant evolution of the virus at the population level, researchers report in the February 8th advance online edition of Nature Medicine. Reuters Health Information 2004 Patients With HIV-1 215 Revertants Face Higher Risk of Failure With Thymidine Analog Therapy Patients carrying a particular mutation in the reverse transcriptase region of the HIV-1 pol gene face an increased risk of virologic failure on regimens that include thymidine analogs, according to a report in the January 23rd issue of AIDS. Reuters Health Information 2004 HIV Recombination May Follow Superinfection With Diverse Strains There are new data suggesting that superinfection with a new strain of HIV in a chronically infected individual can lead to genetic recombination, investigators report. Reuters Health Information 2004 Polypyrimidine Tract-Binding Protein Promotes Rapid Genesis of Insulin Secretory Granules Polypyrimidine tract-binding protein (PTB) promotes rapid biogenesis of insulin secretory granules and may, therefore, represent a therapeutic target in type 2 diabetes, according to a new report. In vivo, downregulation of PTB resulted in depletion of insulin secretory granules from insulinoma cells. Reuters Health Information 2004
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Pulmonary Medicine   Drinking
Fluids During a Cold Not Backed by Medical Evidence A review of the literature published in the Feb. 28 issue of the British Medical Journal found no randomized trials to determine the benefit or harm of this practice, which could be harmful in patients with lower respiratory tract infections. Medscape Medical News 2004  Exercise Improves Pelvic Girdle Pain After Pregnancy In a randomized trial published in the Feb. 15 issue of Spine, specific stabilizing exercises improved pain and function. Medscape Medical News 2004 Cardiology Blacks and Whites Usually Respond Similarly to Antihypertensive Drugs Findings from a meta-analysis of previous trial data reported in the March issue of Hypertension suggest that blacks and whites are more alike than different when it comes to their response to antihypertensive agents. This suggests that physicians should focus less on patient race when prescribing such drugs, the author states. Reuters Health Information 2004
49-year-old bipolar, hypertensive woman with history of burning pain and stiffness. Pain is never gone, and treatments haven't worked. What is the diagnosis? EEG OVERSIGHTS? Is it possible that several episodes of symptoms consistent with a complex partial seizure disorder in a profoundly retarded 24-year-old man would not be detected on a 24-hour EEG? THE NEW COMBINATION TABLET FOR PARKINSON'S DISEASE What is the difference between levodopa/carbidopa and entacapone vs the newly approved combined formulation of these 3 drugs? Are there any special considerations when switching a patient from levodopa/carbidopa and entacapone to the levodopa/carbidopa/entacapone formulation? "COMA" VS "PERSISTENT VEGETATIVE STATE" What is the difference between these? PRIMARY SMALL CELL CARCINOMA OF THE CNS? Looking for doctors who've had experience with a case of "primary" small cell carcinoma of the central nervous system. MELKERSON-ROSENTHAL SYNDROME 12-year-old girl with recurring episodes of facial nerve palsy and orofacial edema; undergoing rehabilitation and taking NSAIDs, to little benefit. How should she be managed?
Internal Medicine  Fruit, Cereal
Fiber May Reduce Cardiovascular Risk Fiber from vegetables was not associated with reduced risk of coronary heart disease, according to a pooled analysis published in the Feb. 23 issue of the Archives of Internal Medicine. Medscape Medical News 2004 Procalcitonin Testing Reduces Antibiotic Use in Lower Respiratory Tract Infections In a randomized intervention trial published in the Feb. 21 issue of The Lancet and posted online Feb. 10, this measurement reduced unnecessary antibiotic use without compromising outcome. Medscape Medical News 2004 Ob/Gyn & Women's Health  Postmenopausal
Hormone Use May Increase Asthma Risk In a prospective cohort study published in the Feb. 23 issue of the Archives of Internal Medicine, postmenopausal women who used hormone therapy were at a higher risk of developing asthma but not chronic obstructive pulmonary disease. Medscape Medical News 2004 Cardiology Infusion of Insulin With Dextrose May Improve Outcome in Acute STEMI Insulin appeared to have an anti-inflammatory and profibrinolytic effect on ST-segment-elevation myocardial infarction, according to the results of a randomized trial published in the Feb. 24 issue of Circulation. Medscape Medical News 2004 Infectious Diseases  Prevalence of
West Nile Virus "Shocking" in U.S. Blood Donors More than 1,000 blood donors have tested positive for West Nile virus in the United States, making the mosquito-borne disease one of the most common illnesses that can be acquired through transfusions, the Centers for Disease Control and Prevention said on Monday. Reuters Health Information 2004 HIV/AIDS Nevirapine May Cause Severe Hepatotoxicity Prodromal signs and symptoms, risk information, and monitoring recommendations have been added to the labeling. Medscape Drug Alert 2004 Neurology & Neurosurgery  Triptan Use
for Migraine Does Not Increase Cardiovascular Risk Triptan drugs, as used in general practice in the UK for treatment of migraine, do not increase the risk of stroke, cardiovascular events, and death, investigators report in the Feb. 24 issue of Neurology. Reuters Health Information 2004 Critical Care Discrepant Autopsy Findings in ICU Patients Remain Common Nearly one third of the autopsies conducted on patients who died while in one intensive care unit in France over a 3-year period revealed major diagnostic errors, physicians report in the Archives of Internal Medicine for Feb. 23. Many of these discrepancies were probably due to false-positive and false-negative findings on diagnostic studies. Reuters Health Information 2004 Pediatrics  Probe of Lead
Investigator in Vaccine-Autism Study Eyed After Lancet Statement
Britain's General Medical Council (GMC) is considering launching an inquiry of Dr. Andrew Wakefield, the man at the center of Britain's MMR vaccine furor, after The Lancet reported undisclosed conflicts of interest in a key article. Reuters Health Information 2004 |
Vitamin D Lowers Inflammation - Along with preventing cancer, arthritis, and osteoporosis, research has revealed that vitamin D lowers C-Reactive Protein (CRP), a measure of inflammation in the body that has been linked to diabetes and heart disease. If you haven't had your vitamin D levels tested, find out why you'll want to consider getting them checked today. "The Weight Optimizing Benefits of Atkins & South Beach, but Then a Whole Lot More" -- at 20% Off for a Limited Time! - See what John Gray, Ph.D., author of a dozen blockbuster bestsellers including the "Men are from Mars, Women are from Venus" series of books, had to say about my new book presenting my entire dietary program in Part One and over 150 brand-new healthy and delicious recipes in Part Two. And for a limited time, take a full 20% off this book that is guaranteed for life to help you avoid disease, optimize weight and live longer!
Not Subscribed to the Newsletter Yet? You can subscribe by filling in your email address in the box to the right, and clicking Subscribe. Six Ways Garlic Can Improve Your Health - Looking for something to fight viruses, fungus and bacteria while preventing heart disease and cancer? Try garlic, an incredibly inexpensive and simple way to improve your health. Outrageous Congressional Abuse - Read how one congressman may have been dealing with drug companies while holding one of the most powerful positions in Congress and drafting legislation involving drug benefits. The potential conflicts of interest are hard to ignore. How to Live Healthy in "Our Toxic World" - Most people are not aware that chemicals in our environment, from the air we breathe to the homes we live in, can cause many of the diseases plaguing the nation such as cancer, obesity, and fertility problems. Find out how what you can do to avoid these toxins and improve your health in this review of Dr. Rapp’s important book, "Our Toxic World: A Wake Up Call." Philadelphia
& Surrounding Cities: Register Now for the Food & Health Expo Where I'll
Be the Keynote on March 21 - Attend the 12th annual Food &
Health Expo on Sunday, March 21 in Philadelphia. I am honored to be this year's
keynote speaker, and will provide a full presentation on How to Fight Disease
& Achieve Total Health, and have a table at the event. Other premier health
speakers will be featured, you'll be able to sample from a wide variety of
foods, and much more -- all for just $15! Can Spirituality Improve Your Health? - Is prayer and spirituality an effective way to improve your health? Find out what the scientific studies have revealed. Odds Are The Drug Industry is Paying Off Your Doctor - Many doctors are unaware that gifts and freebies from the drug companies are significantly influencing their prescribing habits. Find out how to seek the truth about your health without relying on drugs. People Lie More by Phone Than by E-Mail - If you’re concerned someone is lying to you, you may be better of e-mailing them next time! Find out why researchers say it makes sense that more people lie by phone than by e-mail. 10 Interesting Facts on Money - Find out what is less important to Americans than having money and becoming rich. The surprising answers really put what's important in life into perspective. Mercury and Vaccine Link to Autism - There is increasing evidence that exposure to mercury while in the womb is indeed associated with an increased risk of autism and attention-deficit hyperactivity disorder (ADHD). The number of women who have enough mercury in their systems to harm a developing child is shocking. Find out the primary method of exposure to mercury for women of childbearing age. Diet Wars Have Religious Fervor - The ongoing battles between which diet is the best become so intense that they take on a religious fervor. Find out about the diet wars that have been going on for centuries, and learn how to determine which diet is right for you. Get Fit, Increase Energy, and Eliminate Cravings with the Healthiest Convenience Food: Living Fuel Rx - Want to shed pounds, regain energy and live longer but don't always have time to prepare a full meal? Living Fuel Rx -- in Super Greens and new Super Berry -- is the answer. I researched many "healthy" convenience foods, but only Living Fuel Rx provides the total nutrition your body needs. Find out all the ways this all-natural superfood will help you!  Of Tumors,
Genes, and Unsuspected Talents The latest reports from the annual meeting of the American Society of Cell Biology and a debate on genetics vs individual freedom Medscape Molecular Medicine 6(1) 2004 Conference Report - Extracellular Matrix and Cancer: Revisiting Metalloproteinases Has the last word been said on metalloproteinase inhibitors or are new findings raising new hopes? Medscape General Medicine 6(1) 2004 Evaluation of a Deidentification (De-Id) Software Engine to Share Pathology Reports and Clinical Documents for Research In the sixth century BC, the Hippocratic oath made it very clear: "Whatever I shall see or hear in the course of my dealings with patients, it should not be published abroad, I will never divulge, holding such things to be holy secrets." Am J Clin Pathol 121(2) 2004 Relapsing Polychondritis Relapsing polychondritis was first described 80 years ago, and although much has been written about this unusual disease, there continues to be much that we do not know. Curr Opin Rheumatol 16(1) 2004 Neutralization of Free Digoxin-like Immunoreactive Components of Oriental Medicines Dan Shen and Lu-Shen-Wan by the Fab Fragment of Antidigoxin Antibody (Digiband) Traditional Chinese medicines are readily available in health food stores in the United States. Am J Clin Pathol 121(2) 2004 Expression of bcl-6 and CD10 Protein is Associated With Longer Overall Survival and Time to Treatment Failure in Follicular Lymphoma Follicular lymphoma (FL) is one of the most common B-cell lymphomas in Europe and the United States, accounting for 40% of all non-Hodgkin lymphomas. Am J Clin Pathol 121(1) 2004 DYNAMIC CANCER NETWORKS: LATEST FINDINGS Are there new targets still awaiting discovery in anticancer treatments? Catch up on latest findings. Read the Medscape Conference Report "Extracellular Matrix and Cancer: Revisiting Metalloproteinases," NEW in the Biologic Therapies in Cancer Resource Center from Medscape. FROM MEDSCAPE NEUROLOGY/NEUROSURGERY A Practical Approach to Recognizing and Managing Restless Legs Syndrome In this CME activity, learn the proper diagnosis and management of restless legs syndrome, a common movement disorder.  Temporal Lobe
Epilepsy: The Current State of Knowledge Learn about the latest research and practice parameters being used to manage patients with temporal lobe epilepsy. ACE Inhibitors and Secondary TIA Prevention Do ACE inhibitors play a role in the secondary prevention of transient ischemic attacks? Medscape Neurology & Neurosurgery 6(1) 2004  Limb
Contractures in Parkinsonian Patients Although rare, limb contractures associated with PD can lead to severe deformities in hands and feet. Learn about possible etiology, differential diagnosis, and management strategies here. Medscape Neurology & Neurosurgery 6(1) 2004 Fibromyalgia Fibromyalgia is a syndrome characterized by generalized pain, fatigue, disturbed sleep, and numerous unexplained somatic complaints that is present in at least 5% of the general adult population (mostly women) in Western countries. WebMD Scientific American Medicine 2004 Late Complications of Adult Idiopathic Scoliosis Primary Fusions to L4 and Above The authors characterize complications related to primary long fusions using modern 2+ rods and hook/pedicle screw instrumentation methods in the treatment of adult idiopathic scoliosis? Spine 29(3) 2004 Vertebral Body Replacement With an Expandable Cage for Reconstruction After Spinal Tumor Resection Learn about one group's clinical experience with expandable cages used to stabilize the spine after vertebrectomy. Neurosurg Focus 15(5) 2003 FROM OTHER MEDSCAPE SPECIALTIES Abnormal IVP 57 year old presenting with dull, aching right flank discomfort. Appl Radiol Online 3(2) 2004 Behcet Syndrome Behcet syndrome is a systemic vasculitis of small and large vessels of unknown origin. In one prospective study, 20 of the 140 patients with BS were diagnosed as having CNS involvement. Curr Opin Rheumatol 16(1) 2004 MEDSCAPE NEUROLOGY RESOURCE CENTERS Medscape Pain Management Resource Center This Medscape Resource Center provides the latest medical news and clinical information on pain and its management, including reports from recent conferences, review articles, CME programs, and links to clinical practice guidelines and other related resources on the Web. PARKINSONISM-ASSOCIATED LIMB CONTRACTURES What modalities are recommended to overcome these rare, severe deformities in advanced PD? Read "Limb Contractures in Parkinsonian Patients" and join this Ask the Experts discussion, NEW in the Parkinson's Disease Resource Center from Medscape.
MOVEMENT DISORDERS Anxiety and Depression Common Among Patients With Restless Legs Syndrome Patients with restless legs syndrome exhibit relatively high levels of anxiety and depression, according to a report in the February issue of the Journal of Neurology, Neurosurgery, and Psychiatry. Reuters Health Information 2004 ALZHEIMER'S DISEASE AND DEMENTIAS Cognitive Benefits of Galantamine Sustained During Long-term Use In an open-label extension study, this drug slowed cognitive decline in patients with Alzheimer disease during 36 months of continuous use. Medscape Medical News 2004 Testosterone Decline May Add to Impairment in Alzheimer's and Parkinson's The age-related decline in plasma testosterone levels is similar in men with Parkinson's disease (PD) and in those with Alzheimer's disease (AD), researchers report. They say testosterone deficiency "may act as a 'second hit' to impair cognitive function in neurodegenerative disease." Reuters Health Information 2004 Lilly Warns of Zyprexa Risks for Elderly Demented Patients Eli Lilly and Co. on Friday said it has warned doctors that its schizophrenia treatment Zyprexa significantly raises the risk of death and stroke in elderly patients with dementia. Reuters Health Information 2004 HEADACHE AND OTHER PAIN-RELATED TOPICS Topiramate Effective in Preventing Migraines Treatment with the antiepileptic drug topiramate (Topamax) significantly reduces the frequency of migraines. Moreover, the benefits occur within the first month of treatment, researchers report in the February 25th issue of the Journal of the American Medical Association. Reuters Health Information 2004 Triptan Use for Migraine Does Not Increase Cardiovascular Risk Triptan drugs, as used in general practice in the UK for treatment of migraine, do not increase the risk of stroke, cardiovascular events, and death, investigators report in the February 24th issue of Neurology. Reuters Health Information 2004 Increasing Standing Periods for Children With Cerebral Palsy Improves Spine BMD Non-ambulant children with cerebral palsy (CP) have an improved vertebral but not tibial bone mineral density (BMD) after participating in longer periods of standing, according to a report in the February issue of the Archives of Diseases in Childhood. Reuters Health Information 2004 Novel Pathologic Prion Causes Amyloid Plaque in BSE Cattle In a previously undescribed phenotype of bovine spongiform encephalopathy (BSE), amyloid plaques are deposited in cortical areas of the brain, Italian researchers report. The molecular properties of the intracerebral prion protein (PrP) in this amyloidotic form of BSE resemble those associated with one subtype of sporadic Creutzfeldt-Jakob disease (sCJD) in humans. Reuters Health Information 2004 LEGISLATION, POLICY, PRACTICE MANAGEMENT US Mandates Bar Codes on Medicines to Boost Safety Prescription drug makers will be required within two years to put bar codes on packaging in an effort to reduce potentially dangerous dispensing errors in hospitals, U.S. health officials said on Wednesday. Reuters Health Information 2004 Probe of Lead Investigator in Vaccine-Autism Study Eyed After Lancet Statement Britain's General Medical Council (GMC) is considering launching an inquiry of Dr. Andrew Wakefield, the man at the center of Britain's MMR vaccine furor, after The Lancet reported undisclosed conflicts of interest in a key article. Reuters Health Information 2004 |
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Folic Acid
Fortification in US More Effective Than Previously Thought
US Justice
Dept. Seeks Hundreds of Medical Records
Poor
Prognosis for COPD Patients With Do Not Intubate Orders